the strongest loc tite you want to use is red 272 which 'breaks' anywhere from 160-225 ft lbs of torque. now..nothing needs to be any stronger than that. 200 lbs of torque is enough to say, bolt a flywheel to a motor.
272 will meet any normal needs as far as bikes, street cars etc. if your building an airplane, or a top fuel dragster, you should be safety wiring your fasteners anyway.
on a very large surface area fastener, yes you will probably have to use a breaker bar, but theres no need to ' melt it off'.