It's obvious that this poster is about Dental Hygene. Frame 1 is the ADA info. Frame 2 is what happens when creatures use razor blades instead of a toothbrush. Frame 3 is the toothbrush in question. Frame 4 is the dude realizing he should've asked what a toothbrush was.
I know Jermaine has done well for himself and has been consciously been trying to push the boundaries of the gigposter, but this comes across as more of a self-promo poster than an advertisement for a show.